TP53 R174M
Gene Variant Detail

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Gene TP53
Variant R174M
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 R174M lies within the DNA-binding domain of the Tp53 protein (PMID: 21760703). R174M has been identified in the scientific literature (PMID: 7767998, PMID: 29348365), but has not been biochemically characterized and therefore, its effect on Tp53 protein function is unknown (PubMed, Aug 2025).
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon5 TP53 R174M

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Transcript NM_000546.6
gDNA chr17:g.7675091C>A
cDNA c.521G>T
Protein p.R174M
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001407267.1 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001276695.3 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001407264.1 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001276696.3 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001407263.1 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001407270.1 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001126117.2 chr17:g.7673702_7673704delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126113.3 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001126115 chr17:g.7673702_7673704delTCGinsCAT c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001407262.1 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001126112.2 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001407268.1 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001276761.1 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126113.2 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001126115.2 chr17:g.7673702_7673704delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001276697 chr17:g.7670710_7670712delACGinsCAT c.520_522delCGTinsATG p.R174M RefSeq GRCh38/hg38
NM_001126117 chr17:g.7673702_7673704delTCGinsCAT c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001276760.3 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001276695 chr17:g.7674892_7674894delTCGinsCAT c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_000546 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001126116 chr17:g.7673702_7673704delTCGinsCAT c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126114.2 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001126118 chr17:g.7674892_7674894delTCGinsCAT c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001276696.1 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126114.3 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001126118.1 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001276697.1 chr17:g.7670710_7670712delCGTinsATG c.520_522delCGTinsATG p.R174M RefSeq GRCh38/hg38
NM_001276760 chr17:g.7674892_7674894delTCGinsCAT c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126113 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_000546.5 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001126115.1 chr17:g.7673702_7673704delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001407271.1 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126112 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001276761.3 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001407266.1 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001126114 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001276761 chr17:g.7674892_7674894delTCGinsCAT c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126116.2 chr17:g.7673702_7673704delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126117.1 chr17:g.7673702_7673704delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126112.3 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001276760.1 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001276696 chr17:g.7674892_7674894delTCGinsCAT c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_000546.6 chr17:g.7675091C>A c.521G>T p.R174M RefSeq GRCh38/hg38
NM_001407269.1 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126118.2 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001407265.1 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001276695.1 chr17:g.7674892_7674894delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001126116.1 chr17:g.7673702_7673704delCGAinsATG c.520_522delCGAinsATG p.R174M RefSeq GRCh38/hg38
NM_001276697.3 chr17:g.7670710_7670712delCGTinsATG c.520_522delCGTinsATG p.R174M RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
TP53 R174M unknown