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Gene MSH6
Variant G39E
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MSH6 G39E does not lie within any known functional domains of the Msh6 protein (UniProt.org). G39E is a common Msh6 polymorphism (PMID: 31552911, PMID: 24622885, PMID: 19582761), but has not been biochemically characterized and therefore, its effect on Msh6 protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

MSH6 mutant MSH6 G39E

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Transcript NM_000179.3
gDNA chr2:g.47783349G>A
cDNA c.116G>A
Protein p.G39E
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000179 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001281492 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_000179.2 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001281492.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_000179.3 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001407362.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001406796.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001406813.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001406817.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001406809.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001406800.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001406802.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001406795.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001406808.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
XM_024452819.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001406798.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001281492.2 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38
NM_001406803.1 chr2:g.47783349G>A c.116G>A p.G39E RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References