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Gene FGFR2
Variant E160A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 E160A lies within Ig-like C2-type domain 2 of the Fgfr2 protein (UniProt.org). E160A is predicted to disrupt Fgfr2-heparan sulfate interaction and Fgfr dimerization based on structural modeling (PMID: 19147536), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 exon5 FGFR2 E160A

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Transcript NM_000141.5
gDNA chr10:g.121551435T>G
cDNA c.479A>C
Protein p.E160A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001144918.1 chr10:g.121520094T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001320658 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144916.1 chr10:g.121520094T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_017015921.3 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_017015921 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144918.2 chr10:g.121520094T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_022970 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144914.1 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_006717708.3 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144917 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144916 chr10:g.121520094T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_017015921.2 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_006717710.4 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_017015920 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144916.2 chr10:g.121520094T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_000141 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_006717710 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_006717708 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144914 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121564534T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144918 chr10:g.121520094T>G c.479A>C p.E160A RefSeq GRCh38/hg38
NM_001144913 chr10:g.121551435T>G c.479A>C p.E160A RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References