FGFR2 G701S
Gene Variant Detail

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Gene FGFR2
Variant G701S
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 G701S lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). G701S is predicted to inhibit Fgfr2 kinase activity indirectly by structural modeling (PMID: 19147536), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Nov 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 G701S

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Transcript NM_000141.5
gDNA chr10:g.121485489C>T
cDNA c.2101G>A
Protein p.G701S
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121485489C>T c.2101G>A p.G701S RefSeq GRCh38/hg38
NM_001144917.2 chr10:g.121479874C>T c.2101G>A p.G701S RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121485490_121485492delGGGinsAGC c.2101_2103delGGGinsAGC p.G701S RefSeq GRCh38/hg38
NM_022970 chr10:g.121485490_121485492delCCCinsGCT c.2101_2103delGGGinsAGC p.G701S RefSeq GRCh38/hg38
NM_000141 chr10:g.121485489C>T c.2101G>A p.G701S RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121485490_121485492delGGGinsAGC c.2101_2103delGGGinsAGC p.G701S RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121485490_121485492delGGGinsAGC c.2101_2103delGGGinsAGC p.G701S RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121485489C>T c.2101G>A p.G701S RefSeq GRCh38/hg38
NM_001144917.1 chr10:g.121479874C>T c.2101G>A p.G701S RefSeq GRCh38/hg38
NM_001144913 chr10:g.121485490_121485492delCCCinsGCT c.2101_2103delGGGinsAGC p.G701S RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121485490_121485492delGGGinsAGC c.2101_2103delGGGinsAGC p.G701S RefSeq GRCh38/hg38
NM_001144917 chr10:g.121479874C>T c.2101G>A p.G701S RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References