FGFR2 L770V
Gene Variant Detail

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Gene FGFR2
Variant L770V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 L770V lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). L770V is predicted to decrease phospholipase C-gamma activation by Fgfr2 based on structural modeling (PMID: 19147536), but has not been biochemically characterized and therefore, its effect on Fgfr2 protein function is unknown (PubMed, Dec 2025).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 L770V

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Transcript NM_000141.5
gDNA chr10:g.121480015A>C
cDNA c.2308T>G
Protein p.L770V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001320658 chr10:g.121480009G>C c.2308C>G p.L770V RefSeq GRCh38/hg38
NM_000141 chr10:g.121480015A>C c.2308T>G p.L770V RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121480015A>C c.2308T>G p.L770V RefSeq GRCh38/hg38
NM_001320658.2 chr10:g.121480009G>C c.2308C>G p.L770V RefSeq GRCh38/hg38
NM_001320658.1 chr10:g.121480009G>C c.2308C>G p.L770V RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121480015A>C c.2308T>G p.L770V RefSeq GRCh38/hg38
XM_017015921.2 chr10:g.121483742A>C c.2308T>G p.L770V RefSeq GRCh38/hg38
XM_017015921.3 chr10:g.121483742A>C c.2308T>G p.L770V RefSeq GRCh38/hg38
XM_017015921 chr10:g.121483742A>C c.2308T>G p.L770V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References