Gene Variant Detail

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Gene FGFR2
Variant M640I
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions FGFR2 M640I lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). M640I results in proliferation similar to wild-type Fgfr2 in a competition assay and transformation activity similar to wild-type in cultured cells (PMID: 34272467), and therefore, is predicted to have no effect on Fgfr2 protein function.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 M640I

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Transcript NM_000141.5
gDNA chr10:g.121488057C>G
cDNA c.1920G>C
Protein p.M640I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_024447891.1 chr10:g.121483794C>G c.1920G>C p.M640I RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121488057C>G c.1920G>C p.M640I RefSeq GRCh38/hg38
XM_017015924 chr10:g.121483791C>G c.1920G>C p.M640I RefSeq GRCh38/hg38
XM_006717712 chr10:g.121483794C>G c.1920G>C p.M640I RefSeq GRCh38/hg38
XM_017015924.3 chr10:g.121483791C>G c.1920G>C p.M640I RefSeq GRCh38/hg38
XM_024447891.2 chr10:g.121483794C>G c.1920G>C p.M640I RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488057C>G c.1920G>C p.M640I RefSeq GRCh38/hg38
XM_017015924.2 chr10:g.121483791C>G c.1920G>C p.M640I RefSeq GRCh38/hg38
NM_000141 chr10:g.121488057C>G c.1920G>C p.M640I RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR2 M640I Advanced Solid Tumor predicted - sensitive Fexagratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M640I were sensitive to treatment with AZD4547 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 M640I Advanced Solid Tumor predicted - sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M640I were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 M640I Advanced Solid Tumor predicted - sensitive Erdafitinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M640I were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 M640I Advanced Solid Tumor predicted - sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M640I were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 M640I Advanced Solid Tumor predicted - sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M640I were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR2 M640I Advanced Solid Tumor predicted - sensitive E7090 Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR2 M640I were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467