Gene Variant Detail

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Gene ATR
Variant positive
Impact List unknown
Protein Effect unknown
Gene Variant Descriptions ATR positive indicates the presence of ATR gene, mRNA, and/or protein.
Associated Drug Resistance
Category Variants Paths

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No Variant Reference Transcript is Available.
No transcript is Available.

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ATR positive breast cancer predicted - sensitive VE-821 Preclinical - Cell culture Actionable In a preclinical study, human breast cancer cell lines demonstrated sensitivity to VE-821 in culture, resulting in decreased cell survival (PMID: 25468710). 25468710
ATR positive lung cancer sensitive Berzosertib + Cisplatin Preclinical - Pdx & cell culture Actionable In a preclinical study, Berzosertib (VX-970) sensitized patient-derived lung cancer cells to Platinol (cisplatin) in culture and in patient-derived xenograft (PDX) models (PMID: 25010037). 25010037