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Gene | ROS1 |
Variant | G2032R |
Impact List | missense |
Protein Effect | unknown |
Gene Variant Descriptions | ROS1 G2032R lies within the protein kinase domain of the Ros1 protein (UniProt.org). G2032R has been associated with resistance to Ros1 tyrosine kinase inhibitors in the context of ROS1 fusions in patients (PMID: 36135089, PMID: 25033171, PMID: 29477381), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Jan 2024). |
Associated Drug Resistance | Y |
Category Variants Paths |
ROS1 mutant ROS1 G2032R |
Transcript | NM_002944.3 |
gDNA | chr6:g.117317184C>T |
cDNA | c.6094G>A |
Protein | p.G2032R |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_002944.3 | chr6:g.117317184C>T | c.6094G>A | p.G2032R | RefSeq | GRCh38/hg38 |
XM_011536051.2 | chr6:g.117317187C>T | c.6094G>A | p.G2032R | RefSeq | GRCh38/hg38 |
NM_002944.2 | chr6:g.117317184C>T | c.6094G>A | p.G2032R | RefSeq | GRCh38/hg38 |
XM_011536051.3 | chr6:g.117317187C>T | c.6094G>A | p.G2032R | RefSeq | GRCh38/hg38 |
NM_002944 | chr6:g.117317184C>T | c.6094G>A | p.G2032R | RefSeq | GRCh38/hg38 |
Molecular Profile | Protein Effect | Treatment Approaches |
---|---|---|
ROS1 G2032R | unknown | |
ROS1 fusion ROS1 G2032R | ||
ROS1 rearrange ROS1 G2032R |