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Gene HRAS
Variant D33N
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions HRAS D33N lies within the effector region of the Hras protein (UniProt.org). D33N demonstrates decreased binding affinity for effector protein Raf compared to wild-type Hras, and is not transforming in cell culture (PMID: 28686159, PMID: 8035810).
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS inact mut HRAS D33N

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Transcript NM_005343.4
gDNA chr11:g.534226C>T
cDNA c.97G>A
Protein p.D33N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.4 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_001130442 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_176795 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_005343.3 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_176795.5 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_176795.4 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38
NM_005343 chr11:g.534226C>T c.97G>A p.D33N RefSeq GRCh38/hg38

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  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries