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Gene MLH1
Variant D41Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MLH1 D41Y lies within the ATPase domain of the Mlh1 protein (PMID: 22753075). D41Y has not been characterized in the scientific literature and therefore, its effect on Mlh1 protein function is unknown (PubMed, Jul 2024).
Associated Drug Resistance
Category Variants Paths

MLH1 mutant MLH1 D41Y

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Transcript NM_000249.4
gDNA chr3:g.36996623G>T
cDNA c.121G>T
Protein p.D41Y
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001258271.1 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
XM_005265161.2 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_001258271.2 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
XM_005265161 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_001258271 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_001354628.1 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_000249 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_000249.4 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_001354629.2 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_001354630.2 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
XM_005265161.3 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_001354630.1 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_000249.3 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_001354629.1 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
NM_001354628.2 chr3:g.36996623G>T c.121G>T p.D41Y RefSeq GRCh38/hg38
XM_047448152.1 chr3:g.37000967G>T c.121G>T p.D41Y RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
  • Hold down the Shift key and click multiple columns to sort by more than one column. Be sure to set ascending or descending order for a given column before moving on to the next column.

Molecular Profile Protein Effect Treatment Approaches
MLH1 D41Y unknown