Gene Variant Detail

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Gene HRAS
Variant R149Gfs*23
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS R149Gfs*23 indicates a shift in the reading frame starting at amino acid 149 and terminating 23 residues downstream causing a premature truncation of the 189 amino acid Hras protein (UniProt.org). R149Gfs*23 has not been biochemically characterized however, due to the loss of the CAXX motif (PMID: 6087162, PMID: 21924373), is predicted to lead to a loss of Hras protein function resulting in inactivation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS inact mut HRAS R149Gfs*23

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Transcript NM_005343.4
gDNA chr11:g.533460delG
cDNA c.445delC
Protein p.R149Gfs*23
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533460delG c.445delC p.R149Gfs*23 RefSeq GRCh38/hg38
NM_176795 chr11:g.(533458_534325) c.(445_516) p.R149Gfs*23 RefSeq GRCh38/hg38
NM_176795.4 chr11:g.(533458_534325) c.(445_516) p.R149Gfs*23 RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533460delG c.445delC p.R149Gfs*23 RefSeq GRCh38/hg38
NM_176795.5 chr11:g.(533458_534325) c.(445_516) p.R149Gfs*23 RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533460delG c.445delC p.R149Gfs*23 RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533460delG c.445delC p.R149Gfs*23 RefSeq GRCh38/hg38
NM_005343 chr11:g.533460delG c.445delC p.R149Gfs*23 RefSeq GRCh38/hg38
NM_001130442 chr11:g.533460delG c.445delC p.R149Gfs*23 RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References