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Gene | HRAS |
Variant | A59Rfs*32 |
Impact List | frameshift |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | HRAS A59Rfs*32 indicates a shift in the reading frame starting at amino acid 59 and terminating 32 residues downstream causing a premature truncation of the 189 amino acid Hras protein (UniProt.org). Due to the loss of the GTP binding domain (UniProt.org), A59Rfs*32 is predicted to lead to a loss of Hras protein function resulting in inactivation of downstream signaling. |
Associated Drug Resistance | |
Category Variants Paths |
HRAS mutant HRAS inact mut HRAS A59Rfs*32 |
Transcript | NM_005343.4 |
gDNA | chr11:g.533881_533882delCG |
cDNA | c.175_176delGC |
Protein | p.A59Rfs*32 |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |