Gene Variant Detail

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Gene HRAS
Variant A59Rfs*32
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions HRAS A59Rfs*32 indicates a shift in the reading frame starting at amino acid 59 and terminating 32 residues downstream causing a premature truncation of the 189 amino acid Hras protein (UniProt.org). Due to the loss of the GTP binding domain (UniProt.org), A59Rfs*32 is predicted to lead to a loss of Hras protein function resulting in inactivation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS inact mut HRAS A59Rfs*32

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Transcript NM_005343.4
gDNA chr11:g.533881_533882delCG
cDNA c.175_176delGC
Protein p.A59Rfs*32
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_005343 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_001130442 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_176795 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533881_533882delCG c.175_176delGC p.A59Rfs*32 RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
HRAS A59Rfs*32 loss of function - predicted