Gene Variant Detail

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Gene HRAS
Variant G48R
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions HRAS G48R does not lie within any known functional domains of the Hras protein (UniProt.org). G48R demonstrates GTP affinity and GTP hydrolysis activity similar to wild-type Hras, and enhances effector recruitment in combination with HRAS G12V in culture (PMID: 26274561), and therefore, is predicted to have no effect on Hras protein function.
Associated Drug Resistance
Category Variants Paths

HRAS mutant HRAS G48R

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Transcript NM_005343.4
gDNA chr11:g.533914C>T
cDNA c.142G>A
Protein p.G48R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_005343.3 chr11:g.533914C>T c.142G>A p.G48R RefSeq GRCh38/hg38
NM_001130442 chr11:g.533914C>T c.142G>A p.G48R RefSeq GRCh38/hg38
NM_005343.4 chr11:g.533914C>T c.142G>A p.G48R RefSeq GRCh38/hg38
NM_176795.5 chr11:g.533914C>T c.142G>A p.G48R RefSeq GRCh38/hg38
NM_001130442.2 chr11:g.533914C>T c.142G>A p.G48R RefSeq GRCh38/hg38
NM_005343 chr11:g.533914C>T c.142G>A p.G48R RefSeq GRCh38/hg38
NM_001130442.3 chr11:g.533914C>T c.142G>A p.G48R RefSeq GRCh38/hg38
NM_176795 chr11:g.533914C>T c.142G>A p.G48R RefSeq GRCh38/hg38
NM_176795.4 chr11:g.533914C>T c.142G>A p.G48R RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References