NRAS A146V - Gene Variant Detail

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Gene NRAS
Variant A146V
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions NRAS A146V lies within the G domain of the Nras protein (PMID: 17384584). A146V has not been characterized, but can be predicted to lead to a gain of Nras protein function based on the effects of HRAS A146V, which results in increased nucleotide exchange rates, activation of downstream signaling, and transformation of cultured cells (PMID: 24224811, PMID: 21850009, PMID: 3043178).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS A146V

NRAS mutant NRAS exon4 NRAS A146X NRAS A146V

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Transcript NM_002524.5
gDNA chr1:g.114709582G>A
cDNA c.437C>T
Protein p.A146V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114709582G>A c.437C>T p.A146V RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114709582G>A c.437C>T p.A146V RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114709582G>A c.437C>T p.A146V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References