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Gene NRAS
Variant A66V
Impact List missense
Protein Effect unknown
Gene Variant Descriptions NRAS A66V lies within the switch II domain of the Nras protein (PMID: 17384584). A66V has been identified in sequencing studies (PMID: 25127237, PMID: 30458888, PMID: 36902296), but has not been biochemically characterized and therefore, its effect on Nras protein function is unknown (PubMed, Jun 2024).
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon3 NRAS A66V

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Transcript NM_002524.5
gDNA chr1:g.114713893G>A
cDNA c.197C>T
Protein p.A66V
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114713893G>A c.197C>T p.A66V RefSeq GRCh38/hg38
NM_002524 chr1:g.114713893G>A c.197C>T p.A66V RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713893G>A c.197C>T p.A66V RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
NRAS A66V unknown