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Gene NRAS
Variant E132K
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS E132K lies within the G domain of the Nras protein (PMID: 17384584). E132K does not affect cell proliferation or migration, but results in cytoskeletal disruption, decreased expression and aberrant localization of E-cadherin, and decreased cell adhesion compared to wild-type Nras in culture (PMID: 32620824), and therefore, is predicted to lead to a loss of Nras GTPase function.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS E132K

NRAS mutant NRAS exon4 NRAS E132K

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Transcript NM_002524.5
gDNA chr1:g.114709625C>T
cDNA c.394G>A
Protein p.E132K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.4 chr1:g.114709625C>T c.394G>A p.E132K RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114709625C>T c.394G>A p.E132K RefSeq GRCh38/hg38
NM_002524 chr1:g.114709625C>T c.394G>A p.E132K RefSeq GRCh38/hg38

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References