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| Gene | NRAS |
| Variant | P34A |
| Impact List | missense |
| Protein Effect | unknown |
| Gene Variant Descriptions | NRAS P34A lies within the switch I domain of the Nras protein (PMID: 17384584). P34A has not been characterized in the scientific literature and therefore, its effect on Nras protein function is unknown (PubMed, Mar 2026). |
| Associated Drug Resistance | |
| Category Variants Paths |
NRAS mutant NRAS exon2 NRAS P34A |
| Transcript | NM_002524.5 |
| gDNA | chr1:g.114716061G>C |
| cDNA | c.100C>G |
| Protein | p.P34A |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_002524.5 | chr1:g.114716061G>C | c.100C>G | p.P34A | RefSeq | GRCh38/hg38 |
| NM_002524 | chr1:g.114716061G>C | c.100C>G | p.P34A | RefSeq | GRCh38/hg38 |
| NM_002524.4 | chr1:g.114716061G>C | c.100C>G | p.P34A | RefSeq | GRCh38/hg38 |
| Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
|---|