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Gene MLH1
Variant I190T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions MLH1 I190T lies within the ATPase domain of the Mlh1 protein (PMID: 22753075). I190T has not been characterized in the scientific literature and therefore, its effect on Mlh1 protein function is unknown (PubMed, Nov 2023).
Associated Drug Resistance
Category Variants Paths

MLH1 mutant MLH1 I190T

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Transcript NM_000249.4
gDNA chr3:g.37011843T>C
cDNA c.569T>C
Protein p.I190T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_005265161 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
NM_000249.3 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
XM_005265161.3 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
NM_001258271 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
NM_001354628.2 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
NM_000249.4 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
NM_000249 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
NM_001354628.1 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
NM_001354630.1 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
NM_001258271.2 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
XM_005265161.2 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
NM_001354630.2 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38
NM_001258271.1 chr3:g.37011843T>C c.569T>C p.I190T RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References