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| Gene | PTEN |
| Variant | negative |
| Impact List | unknown |
| Protein Effect | loss of function |
| Gene Variant Descriptions | PTEN negative indicates a lack of the PTEN gene, mRNA, and/or protein. |
| Associated Drug Resistance | |
| Category Variants Paths |
PTEN mutant PTEN inact mut PTEN negative |
| Molecular Profile | Protein Effect | Treatment Approaches |
|---|---|---|
| PTEN negative | loss of function | Akt Inhibitor (Pan) Akt1 Inhibitor Akt2 Inhibitor PI3K Inhibitor (Pan) PIK3CB inhibitor |
| BRAF V600X PTEN neg | ||
| PTEN neg RB1 R255* | ||
| PTEN L152P PTEN neg |