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| Gene | NRAS |
| Variant | Q22K |
| Impact List | missense |
| Protein Effect | unknown |
| Gene Variant Descriptions | NRAS Q22K lies within the G domain of the Nras protein (PMID: 17384584). Q22K has been identified in the scientific literature (PMID: 31795494, PMID: 27168466, PMID: 22817889), but has not been biochemically characterized and therefore, its effect on Nras protein function is unknown (PubMed, Mar 2026). |
| Associated Drug Resistance | |
| Category Variants Paths |
NRAS mutant NRAS exon2 NRAS Q22K |
| Transcript | NM_002524.5 |
| gDNA | chr1:g.114716097G>T |
| cDNA | c.64C>A |
| Protein | p.Q22K |
| Source Database | RefSeq |
| Genome Build | GRCh38/hg38 |
| Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
|---|---|---|---|---|---|
| NM_002524.4 | chr1:g.114716097G>T | c.64C>A | p.Q22K | RefSeq | GRCh38/hg38 |
| NM_002524.5 | chr1:g.114716097G>T | c.64C>A | p.Q22K | RefSeq | GRCh38/hg38 |
| NM_002524 | chr1:g.114716097G>T | c.64C>A | p.Q22K | RefSeq | GRCh38/hg38 |
| Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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