NRAS T50I
Gene Variant Detail

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Gene NRAS
Variant T50I
Impact List missense
Protein Effect gain of function - predicted
Gene Variant Descriptions NRAS T50I does not lie within any known functional domains of the Nras protein (UniProt.org). T50I has no effect on the intrinsic Nras GTPase activity and sensitivity to GTPase-activating proteins or guanine nucleotide exchange factor, but increases phosphorylation of Erk and Mel in cell culture (PMID: 19966803), potentially through altering Nras membrane orientation and strengthening effector binding based on structural modeling of the Hras protein (PMID: 18273062), and therefore, is predicted to lead to a gain of Nras protein function.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS act mut NRAS T50I

NRAS mutant NRAS exon3 NRAS T50I

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Transcript NM_002524.5
gDNA chr1:g.114713941G>A
cDNA c.149C>T
Protein p.T50I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114713941G>A c.149C>T p.T50I RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713941G>A c.149C>T p.T50I RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713941G>A c.149C>T p.T50I RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Protein Effect Treatment Approaches
NRAS T50I gain of function - predicted MEK inhibitor (Pan) MEK1 Inhibitor MEK2 Inhibitor PI3K Inhibitor (Pan) PIK3CA inhibitor RAS Inhibitor (Pan)