NRAS Y40*
Gene Variant Detail

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Gene NRAS
Variant Y40*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS Y40* results in a premature truncation of the Nras protein at amino acid 40 of 189 (UniProt.org). Due to the loss of GTP binding regions (UniProt.org), Y40* is predicted to lead to a loss of Nras protein function resulting in inactivation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS exon3 NRAS Y40*

NRAS mutant NRAS inact mut NRAS Y40*

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Transcript NM_002524.5
gDNA chr1:g.114713970G>T
cDNA c.120C>A
Protein p.Y40*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524 chr1:g.114713970G>T c.120C>A p.Y40* RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114713970G>T c.120C>A p.Y40* RefSeq GRCh38/hg38
NM_002524.5 chr1:g.114713970G>T c.120C>A p.Y40* RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
NRAS Y40* loss of function - predicted