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Gene NRAS
Variant E162*
Impact List nonsense
Protein Effect loss of function - predicted
Gene Variant Descriptions NRAS E162* results in a premature truncation of the Nras protein at amino acid 162 of 189 (UniProt.org). Due to the loss of the CAAX motif (PMID: 6087162, PMID: 21924373), E162* is predicted to lead to a loss of Nras protein function resulting in inactivation of downstream signaling.
Associated Drug Resistance
Category Variants Paths

NRAS mutant NRAS inact mut NRAS E162*

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Transcript NM_002524.5
gDNA chr1:g.114708621C>A
cDNA c.484G>T
Protein p.E162*
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002524.5 chr1:g.114708621C>A c.484G>T p.E162* RefSeq GRCh38/hg38
NM_002524 chr1:g.114708621C>A c.484G>T p.E162* RefSeq GRCh38/hg38
NM_002524.4 chr1:g.114708621C>A c.484G>T p.E162* RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References