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Gene FLT3
Variant E611fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions FLT3 E611fs results in a change in the amino acid sequence of the Flt3 protein beginning at aa 611 of 993, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), E611fs is predicted to lead to a loss of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 E611fs

FLT3 mutant FLT3 inact mut FLT3 E611fs

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Transcript NM_004119.3
gDNA chr13:g.(28034088_28034089)
cDNA c.(1831_1830)
Protein p.E611fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.28034086_28034087insG c.1832_1833insC p.E611fs*23 RefSeq GRCh38/hg38
XM_017020487 chr13:g.28023411_28023412insAACGGGGGGG c.1831_1832insCCCCCCCGTT p.E611fs*23 RefSeq GRCh38/hg38
XM_011535018 chr13:g.28023411_28023412insAACGGGGGGG c.1831_1832insCCCCCCCGTT p.E611fs*23 RefSeq GRCh38/hg38
XM_011535018.2 chr13:g.(28023412_28023413) c.(1831_1830) p.E611fs RefSeq GRCh38/hg38
NM_004119.3 chr13:g.(28034088_28034089) c.(1831_1830) p.E611fs RefSeq GRCh38/hg38
XM_011535018.3 chr13:g.(28023412_28023413) c.(1831_1830) p.E611fs RefSeq GRCh38/hg38
XM_011535017.2 chr13:g.(28023412_28023413) c.(1831_1830) p.E611fs RefSeq GRCh38/hg38
XM_047430216.1 chr13:g.(28023412_28023413) c.(1831_1830) p.E611fs RefSeq GRCh38/hg38
XM_011535017 chr13:g.28023411_28023412insAACGGGGGGG c.1831_1832insCCCCCCCGTT p.E611fs*23 RefSeq GRCh38/hg38
NM_004119.2 chr13:g.(28034088_28034089) c.(1831_1830) p.E611fs RefSeq GRCh38/hg38
XM_017020487.1 chr13:g.(28023412_28023413) c.(1831_1830) p.E611fs RefSeq GRCh38/hg38

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References