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Gene FLT3
Variant F612fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions FLT3 F612fs results in a change in the amino acid sequence of the Flt3 protein beginning at aa 612 of 993, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), F612fs is predicted to lead to a loss of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 F612fs

FLT3 mutant FLT3 inact mut FLT3 F612fs

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Transcript NM_004119.3
gDNA chr13:g.(28034085_28034086)
cDNA c.(1834_1833)
Protein p.F612fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.(28034085_28034086) c.(1834_1833) p.F612fs RefSeq GRCh38/hg38
NM_004119.3 chr13:g.(28034085_28034086) c.(1834_1833) p.F612fs RefSeq GRCh38/hg38
NM_004119 chr13:g.28034085_28034086insG c.1833_1834insC p.F612fs*22 RefSeq GRCh38/hg38

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Clinical Trial Phase Therapies Title Recruitment Status Covered Countries Other Countries