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Gene FLT3
Variant R607fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions FLT3 R607fs results in a change in the amino acid sequence of the Flt3 protein beginning at aa 607 of 993, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), R607fs is predicted to lead to a loss of Flt3 protein function.
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon14 FLT3 R607fs

FLT3 mutant FLT3 inact mut FLT3 R607fs

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Transcript NM_004119.3
gDNA chr13:g.(28034100_28034101)
cDNA c.(1819_1818)
Protein p.R607fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.(28034100_28034101) c.(1819_1818) p.R607fs RefSeq GRCh38/hg38
NM_004119.3 chr13:g.(28034100_28034101) c.(1819_1818) p.R607fs RefSeq GRCh38/hg38
NM_004119 chr13:g.28034100_28034101insC c.1818_1819insG p.R607fs*27 RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Protein Effect Treatment Approaches
FLT3 R607fs loss of function - predicted