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Gene | FLT3 |
Variant | K438fs |
Impact List | frameshift |
Protein Effect | loss of function - predicted |
Gene Variant Descriptions | FLT3 K438fs results in a change in the amino acid sequence of the Flt3 protein beginning at aa 438 of 993, likely resulting in premature truncation of the functional protein (UniProt.org). Due to the loss of the protein kinase domain (UniProt.org), K438fs is predicted to lead to a loss of Flt3 protein function. |
Associated Drug Resistance | |
Category Variants Paths |
FLT3 mutant FLT3 inact mut FLT3 K438fs |
Transcript | NM_004119.3 |
gDNA | chr13:g.(28036041_28036042) |
cDNA | c.(1312_1311) |
Protein | p.K438fs |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004119 | chr13:g.(28036041_28036042) | c.(1312_1311) | p.K438fs | RefSeq | GRCh38/hg38 |
NM_004119.2 | chr13:g.(28036041_28036042) | c.(1312_1311) | p.K438fs | RefSeq | GRCh38/hg38 |
NM_004119.3 | chr13:g.(28036041_28036042) | c.(1312_1311) | p.K438fs | RefSeq | GRCh38/hg38 |
Clinical Trial | Phase | Therapies | Title | Recruitment Status | Covered Countries | Other Countries |
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