Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | FLT3 |
Variant | K826fs |
Impact List | frameshift |
Protein Effect | unknown |
Gene Variant Descriptions | FLT3 K826fs results in a change in the amino acid sequence of the Flt3 protein beginning at aa 826 of 993, likely resulting in premature truncation of the functional protein (UniProt.org). K826fs has not been characterized in the scientific literature and therefore, its effect on Flt3 protein function is unknown (PubMed, Apr 2024). |
Associated Drug Resistance | |
Category Variants Paths |
FLT3 mutant FLT3 exon20 FLT3 K826fs |
Transcript | NM_004119.3 |
gDNA | chr13:g.(28018532_28018533) |
cDNA | c.(2476_2475) |
Protein | p.K826fs |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_004119.3 | chr13:g.(28018532_28018533) | c.(2476_2475) | p.K826fs | RefSeq | GRCh38/hg38 |
NM_004119 | chr13:g.(28018532_28018533) | c.(2476_2475) | p.K826fs | RefSeq | GRCh38/hg38 |
NM_004119.2 | chr13:g.(28018532_28018533) | c.(2476_2475) | p.K826fs | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|