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Gene FLT3
Variant L850fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions FLT3 L850fs results in a change in the amino acid sequence of the Flt3 protein beginning at aa 850 of 993, likely resulting in premature truncation of the functional protein (UniProt.org). L850fs has not been characterized in the scientific literature and therefore, its effect on Flt3 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon21 FLT3 L850fs

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Transcript NM_004119.3
gDNA chr13:g.(28015695_28015696)
cDNA c.(2548_2547)
Protein p.L850fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119 chr13:g.(28015695_28015696) c.(2548_2547) p.L850fs RefSeq GRCh38/hg38
NM_004119.2 chr13:g.(28015695_28015696) c.(2548_2547) p.L850fs RefSeq GRCh38/hg38
NM_004119.3 chr13:g.(28015695_28015696) c.(2548_2547) p.L850fs RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References