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Gene FLT3
Variant R849fs
Impact List frameshift
Protein Effect unknown
Gene Variant Descriptions FLT3 R849fs results in a change in the amino acid sequence of the Flt3 protein beginning at aa 849 of 993, likely resulting in premature truncation of the functional protein (UniProt.org). R849fs has not been characterized in the scientific literature and therefore, its effect on Flt3 protein function is unknown (PubMed, Apr 2024).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 exon21 FLT3 R849fs

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Transcript NM_004119.3
gDNA chr13:g.(28015698_28015699)
cDNA c.(2545_2544)
Protein p.R849fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.3 chr13:g.(28015698_28015699) c.(2545_2544) p.R849fs RefSeq GRCh38/hg38
NM_004119 chr13:g.(28015698_28015699) c.(2545_2544) p.R849fs RefSeq GRCh38/hg38
NM_004119.2 chr13:g.(28015698_28015699) c.(2545_2544) p.R849fs RefSeq GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References