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Gene APC
Variant V1352A
Impact List missense
Protein Effect unknown
Gene Variant Descriptions APC V1352A lies within the beta-catenin binding and downregulation region of the Apc protein (PMID: 14672538). V1352A has been identified in sequencing studies (PMID: 26530882, PMID: 29069792), but has not been biochemically characterized and therefore, its effect on Apc protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

APC mutant APC V1352A

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Transcript NM_000038.6
gDNA chr5:g.112839649T>C
cDNA c.4055T>C
Protein p.V1352A
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354895.2 chr5:g.112839649T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_001127510.3 chr5:g.112839649T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_001407467.1 chr5:g.112840036T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_001354898.2 chr5:g.112839724T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_001127510 chr5:g.112839649T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_001407469.1 chr5:g.112840036T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_000038.5 chr5:g.112839649T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_000038.6 chr5:g.112839649T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_001354895.1 chr5:g.112839649T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_000038 chr5:g.112839649T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_001127510.2 chr5:g.112839649T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_001354898.1 chr5:g.112839724T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38
NM_001407450.1 chr5:g.112839649T>C c.4055T>C p.V1352A RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References