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Gene CHEK2
Variant T366fs
Impact List frameshift
Protein Effect loss of function - predicted
Gene Variant Descriptions CHEK2 T366fs results in a change in the amino acid sequence of the Chek2 protein beginning at aa 366 of 543, likely resulting in premature truncation of the functional protein (UniProt.org). T366fs is predicted to confer a loss of function to the Chek2 protein as demonstrated by loss of kinase activity (PMID: 11053450).
Associated Drug Resistance
Category Variants Paths

CHEK2 mutant CHEK2 inact mut CHEK2 T366fs

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Transcript NM_001005735.2
gDNA chr22:g.(28699879_28699880)
cDNA c.(1096_1095)
Protein p.T366fs
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001005735 chr22:g.(28696982_28699879) c.(1096_1143) p.T366fs*15 RefSeq GRCh38/hg38
XM_047441105.1 chr22:g.(28699879_28699880) c.(1096_1095) p.T366fs RefSeq GRCh38/hg38
NM_001005735.1 chr22:g.(28699879_28699880) c.(1096_1095) p.T366fs RefSeq GRCh38/hg38
NM_001005735.2 chr22:g.(28699879_28699880) c.(1096_1095) p.T366fs RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References