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Gene FGFR3
Variant K650N
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR3 K650N lies within the protein kinase domain of the Fgfr3 protein (UniProt.org). K650N confers a gain of function to the Fgfr3 protein as demonstrated by constitutive activation (PMID: 11055896), a growth advantage in a competition assay, and increased transformation activity in cultured cells (PMID: 34272467).
Associated Drug Resistance
Category Variants Paths

FGFR3 mutant FGFR3 act mut FGFR3 K650N

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Transcript NM_000142.5
gDNA chr4:g.1806164G>C
cDNA c.1950G>C
Protein p.K650N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001354810.2 chr4:g.1806161G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
XM_011513422.2 chr4:g.1806161G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
XM_047449824.1 chr4:g.1806164G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
NM_001354809.2 chr4:g.1806161G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
XM_047449822.1 chr4:g.1806161G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
XM_011513422 chr4:g.1806161G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
XM_006713873 chr4:g.1806164G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
XM_006713873.2 chr4:g.1806164G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
XM_011513422.1 chr4:g.1806161G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
XM_006713872 chr4:g.1806161G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
NM_001354809.1 chr4:g.1806161G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
NM_000142.5 chr4:g.1806164G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
NM_000142 chr4:g.1806164G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
NM_001354810.1 chr4:g.1806161G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
NM_000142.4 chr4:g.1806164G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
XM_006713873.1 chr4:g.1806164G>C c.1950G>C p.K650N RefSeq GRCh38/hg38
XM_047449823.1 chr4:g.1806164G>C c.1950G>C p.K650N RefSeq GRCh38/hg38

Filtering

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FGFR3 K650N Advanced Solid Tumor sensitive Infigratinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR3 K650N were sensitive to treatment with Truseltiq (infigratinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR3 K650N Advanced Solid Tumor sensitive Erdafitinib Preclinical - Cell line xenograft Actionable In a preclinical study, cells expressing FGFR3 K650N were sensitive to treatment with Balversa (erdafitinib) in culture, demonstrating reduced cell viability, and Balversa (erdafitinib) treatment led to inhibition of tumor growth in a cell line xenograft model (PMID: 34272467). 34272467
FGFR3 K650N Advanced Solid Tumor sensitive Futibatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR3 K650N were sensitive to treatment with Lytgobi (futibatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR3 K650N Advanced Solid Tumor sensitive Pemigatinib Preclinical - Cell culture Actionable In a preclinical study, cells expressing FGFR3 K650N were sensitive to treatment with Pemazyre (pemigatinib) in culture, demonstrating reduced cell viability (PMID: 34272467). 34272467
FGFR3 K650N Advanced Solid Tumor sensitive E7090 Preclinical - Cell line xenograft Actionable In a preclinical study, cells expressing FGFR3 K650N were sensitive to treatment with E7090 in culture, demonstrating reduced cell viability, and E7090 treatment led to inhibition of tumor growth in a cell line xenograft model (PMID: 34272467). 34272467