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Gene ROS1
Variant D2033N
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 D2033N lies within the protein kinase domain of the Ros1 protein (UniProt.org). D2033N has been demonstrated to confer resistance to Ros1 tyrosine kinase inhibitors and increase cell migration and invasion in the context of Ros1 fusions in culture (PMID: 36265718, PMID: 26673800), but has not been individually characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance Y
Category Variants Paths

ROS1 mutant ROS1 D2033N

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Transcript NM_002944.3
gDNA chr6:g.117317181C>T
cDNA c.6097G>A
Protein p.D2033N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.3 chr6:g.117317181C>T c.6097G>A p.D2033N RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117317181C>T c.6097G>A p.D2033N RefSeq GRCh38/hg38
NM_002944 chr6:g.117317181C>T c.6097G>A p.D2033N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
ROS1 D2033N Advanced Solid Tumor predicted - sensitive Lorlatinib Preclinical - Biochemical Actionable In a preclinical study, Lorbrena (lorlatinib) inhibited kinase activity of a transformed cell line expressing ROS1 D2033N in culture (PMID: 32918045). 32918045
ROS1 D2033N Advanced Solid Tumor predicted - sensitive Foritinib Preclinical - Biochemical Actionable In a preclinical study, Foritinib inhibited the kinase activity of a transformed cell line expressing ROS1 D2033N in culture (PMID: 32918045). 32918045