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Gene FLT3
Variant N841I
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FLT3 N841I lies within the protein kinase domain of the Flt3 protein (UniProt.org). N841I results in constitutive phosphorylation of Flt3, activation of Akt and Mapk signalling pathways, leading to leukemogenicity in animal models (PMID: 15178581).
Associated Drug Resistance
Category Variants Paths

FLT3 mutant FLT3 act mut FLT3 N841I

FLT3 mutant FLT3 exon20 FLT3 N841I

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Transcript NM_004119.3
gDNA chr13:g.28018486T>A
cDNA c.2522A>T
Protein p.N841I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_004119.2 chr13:g.28018486T>A c.2522A>T p.N841I RefSeq GRCh38/hg38
NM_004119 chr13:g.28018486T>A c.2522A>T p.N841I RefSeq GRCh38/hg38
NM_004119.3 chr13:g.28018486T>A c.2522A>T p.N841I RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References
FLT3 N841I hematologic cancer sensitive Gilteritinib Preclinical - Cell culture Actionable In a preclinical study, Xospata (gilteritinib) resulted in reduced cell viability in transformed cells expressing FLT3 N841I in culture (PMID: 32040554). 32040554