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Gene KIT
Variant I653T
Impact List missense
Protein Effect unknown
Gene Variant Descriptions KIT I653T lies within the protein kinase domain (exon 13) of the Kit protein (UniProt.org). I653T has been identified in the scientific literature (PMID: 21690468), but has not been been biochemically characterized and therefore, its effect on Kit protein function is unknown (PubMed, Nov 2024).
Associated Drug Resistance
Category Variants Paths

KIT mutant KIT exon13 KIT I653T

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Transcript NM_000222.3
gDNA chr4:g.54728089T>C
cDNA c.1958T>C
Protein p.I653T
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001385285.1 chr4:g.54728089T>C c.1958T>C p.I653T RefSeq GRCh38/hg38
XM_017008178.1 chr4:g.54728089T>C c.1958T>C p.I653T RefSeq GRCh38/hg38
XM_017008178 chr4:g.54728089T>C c.1958T>C p.I653T RefSeq GRCh38/hg38
NM_000222.3 chr4:g.54728089T>C c.1958T>C p.I653T RefSeq GRCh38/hg38
NM_000222 chr4:g.54728089T>C c.1958T>C p.I653T RefSeq GRCh38/hg38
NM_000222.2 chr4:g.54728089T>C c.1958T>C p.I653T RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References