FBXW7 K11R
Gene Variant Detail

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Gene FBXW7
Variant K11R
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions FBXW7 K11R does not lie within any known functional domains of the Fbxw7 protein (UniProt.org). K11R results in slowed Fbxw7 degradation in an in vitro assay (PMID: 33824312), but disruption of the NSL1 function of the Fbxw7 protein in cell culture (PMID: 20815813), and therefore, is predicted to lead to a loss of Fbxw7 protein function.
Associated Drug Resistance
Category Variants Paths

FBXW7 mutant FBXW7 inact mut FBXW7 K11R

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Transcript NM_001349798.2
gDNA chr4:g.152411772T>C
cDNA c.32A>G
Protein p.K11R
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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