TP53 C238Y
Gene Variant Detail

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Gene TP53
Variant C238Y
Impact List missense
Protein Effect unknown
Gene Variant Descriptions TP53 C238Y lies within the DNA-binding domain of the Tp53 protein (PMID: 22713868). C238Y demonstrates binding to MDM2 and phosphorylation at Serine 15, results in transactivation the Tp53 target gene p21 similar to wild-type Tp53 in cell culture, and does not significantly alter Tp53 structure in molecular models (PMID: 16818505), however, results in aberrant transactivation of Ctnnb1 in culture (PMID: 37537199), and therefore, its effect on Tp53 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

TP53 mutant TP53 exon7 TP53 C238Y

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Transcript NM_000546.6
gDNA chr17:g.7674250C>T
cDNA c.713G>A
Protein p.C238Y
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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