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Gene ROS1
Variant Y382H
Impact List missense
Protein Effect unknown
Gene Variant Descriptions ROS1 Y382H lies within the extracellular domain of the Ros1 protein (UniProt.org). Y382H has been identified in sequencing studies (PMID: 29981866, PMID: 38159331), but has not been biochemically characterized and therefore, its effect on Ros1 protein function is unknown (PubMed, Mar 2024).
Associated Drug Resistance
Category Variants Paths

ROS1 mutant ROS1 Y382H

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Transcript NM_002944.3
gDNA chr6:g.117394182A>G
cDNA c.1144T>C
Protein p.Y382H
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_002944.3 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
XM_011536051.3 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
XM_017011172 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
XM_017011173 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
NM_002944 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
NM_002944.2 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
XM_017011173.2 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
XM_017011173.1 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
XM_011536051 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
XM_017011172.1 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
XM_017011172.2 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38
XM_011536051.2 chr6:g.117394182A>G c.1144T>C p.Y382H RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References