Missing content? – Request curation!
Request curation for specific Genes, Variants, or PubMed publications.
Have questions, comments, or suggestions? - Let us know!
Email us at : ckbsupport@genomenon.com
Gene | PTEN |
Variant | I168F |
Impact List | missense |
Protein Effect | no effect - predicted |
Gene Variant Descriptions | PTEN I168F lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). I168F demonstrates phosphatase activity similar to wild-type Pten in yeast (PMID: 21828076), and therefore, is predicted to have no effect on Pten protein function. |
Associated Drug Resistance | |
Category Variants Paths |
PTEN mutant PTEN I168F |
Transcript | NM_000314.8 |
gDNA | chr10:g.87952127A>T |
cDNA | c.502A>T |
Protein | p.I168F |
Source Database | RefSeq |
Genome Build | GRCh38/hg38 |
Transcript | gDNA | cDNA | Protein | Source Database | Genome Build |
---|---|---|---|---|---|
NM_000314.6 | chr10:g.87952127A>T | c.502A>T | p.I168F | RefSeq | GRCh38/hg38 |
NM_000314.8 | chr10:g.87952127A>T | c.502A>T | p.I168F | RefSeq | GRCh38/hg38 |
NM_000314 | chr10:g.87952127A>T | c.502A>T | p.I168F | RefSeq | GRCh38/hg38 |
Molecular Profile | Indication/Tumor Type | Response Type | Therapy Name | Approval Status | Evidence Type | Efficacy Evidence | References |
---|