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Gene FGFR2
Variant K659N
Impact List missense
Protein Effect gain of function
Gene Variant Descriptions FGFR2 K659N (also referred to as K660N from the FGFR2IIIb isoform) lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). K659N results in proliferation similar to wild-type Fgfr2 in a competition assay (PMID: 34272467) but confers a gain of function to the Fgfr2 protein as demonstrated by increased autophosphorylation and phosphorylation of downstream targets, Mek and Stat3 (PMID: 23527311), and increased transformation activity in cultured cells (PMID: 34272467).
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 act mut FGFR2 K659N

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Transcript NM_000141.5
gDNA chr10:g.121488000C>G
cDNA c.1977G>C
Protein p.K659N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
XM_006717708.3 chr10:g.121488054T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
NM_001144913 chr10:g.121488003T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
XM_006717708 chr10:g.121488054T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488003T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
XM_006717708.4 chr10:g.121488054T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
NM_022970 chr10:g.121488003T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
NM_022970.3 chr10:g.121488003T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
NM_001144913.1 chr10:g.121488003T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121488000C>G c.1977G>C p.K659N RefSeq GRCh38/hg38
XM_017015920 chr10:g.121488054T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
XM_017015920.3 chr10:g.121488054T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
XM_017015920.2 chr10:g.121488054T>G c.1977A>C p.K659N RefSeq GRCh38/hg38
NM_000141.5 chr10:g.121488000C>G c.1977G>C p.K659N RefSeq GRCh38/hg38
NM_000141 chr10:g.121488000C>G c.1977G>C p.K659N RefSeq GRCh38/hg38
NM_022970.4 chr10:g.121488003T>G c.1977A>C p.K659N RefSeq GRCh38/hg38

Filtering

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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Protein Effect Treatment Approaches
FGFR2 K659N gain of function FGFR Inhibitor (Pan) FGFR2 Inhibitor