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Gene FGFR2
Variant E731K
Impact List missense
Protein Effect unknown
Gene Variant Descriptions FGFR2 E731K lies within the protein kinase domain of the Fgfr2 protein (UniProt.org). E731K results in increased phosphorylation of Fgfr2, Erk signaling, and transcriptional activation of Runx2 in culture (PMID: 21928350), however in another study, results in cell proliferation and viability levels similar to wild-type Fgfr2 in two different cell lines (PMID: 29533785), and therefore, its effect on Fgfr2 protein function is unknown.
Associated Drug Resistance
Category Variants Paths

FGFR2 mutant FGFR2 E731K

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Transcript NM_000141.5
gDNA chr10:g.121485399C>T
cDNA c.2191G>A
Protein p.E731K
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000141.5 chr10:g.121485399C>T c.2191G>A p.E731K RefSeq GRCh38/hg38
XM_006717710 chr10:g.121485459C>T c.2191G>A p.E731K RefSeq GRCh38/hg38
NM_000141.4 chr10:g.121485399C>T c.2191G>A p.E731K RefSeq GRCh38/hg38
XM_006717710.5 chr10:g.121485459C>T c.2191G>A p.E731K RefSeq GRCh38/hg38
XM_006717710.4 chr10:g.121485459C>T c.2191G>A p.E731K RefSeq GRCh38/hg38
NM_000141 chr10:g.121485399C>T c.2191G>A p.E731K RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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Molecular Profile Protein Effect Treatment Approaches
FGFR2 E731K unknown