PTEN D301N
Gene Variant Detail

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Gene PTEN
Variant D301N
Impact List missense
Protein Effect no effect - predicted
Gene Variant Descriptions PTEN D301N lies within the C2 tensin-type domain of the Pten protein (UniProt.org). D301N demonstrates inhibition of Akt phosphorylation similar to wild-type Pten in cell culture (PMID: 19329485), and therefore, is predicted to have no effect on Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN D301N

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Transcript NM_000314.8
gDNA chr10:g.87960993G>A
cDNA c.901G>A
Protein p.D301N
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.8 chr10:g.87960993G>A c.901G>A p.D301N RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87960993G>A c.901G>A p.D301N RefSeq GRCh38/hg38
NM_000314 chr10:g.87960993G>A c.901G>A p.D301N RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References