Gene Variant Detail

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Gene PTEN
Variant K128R
Impact List missense
Protein Effect no effect
Gene Variant Descriptions PTEN K128R lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). K128R demonstrates inhibition of Akt phosphorylation at similar levels of wild-type Pten in cell culture (PMID: 16829519, PMID: 29739874) and therefore, has no effect on Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN K128R

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Transcript NM_000314.8
gDNA chr10:g.87933142A>G
cDNA c.383A>G
Protein p.K128R
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314.6 chr10:g.87933142A>G c.383A>G p.K128R RefSeq GRCh38/hg38
NM_000314 chr10:g.87933142A>G c.383A>G p.K128R RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87933142A>G c.383A>G p.K128R RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References