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Gene PTEN
Variant L23F
Impact List missense
Protein Effect loss of function
Gene Variant Descriptions PTEN L23F lies within the phosphatase tensin-type domain of the Pten protein (UniProt.org). L23F retains phosphatase activity, but results in nuclear accumulation of Pten and failure to inhibit Akt phosphorylation and cell proliferation in culture (PMID: 17213812) and therefore, confers a loss of function to the Pten protein.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN L23F

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Transcript NM_000314.8
gDNA chr10:g.87864538A>T
cDNA c.69A>T
Protein p.L23F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001304718.2 chr10:g.87957876_87957878delCTAinsTTT c.67_69delCTAinsTTT p.L23F RefSeq GRCh38/hg38
NM_001304718 chr10:g.87957876_87957878delCTAinsTTT c.67_69delCTAinsTTT p.L23F RefSeq GRCh38/hg38
NM_001304718.1 chr10:g.87957876_87957878delCTAinsTTT c.67_69delCTAinsTTT p.L23F RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87864538A>T c.69A>T p.L23F RefSeq GRCh38/hg38
NM_000314 chr10:g.87864538A>T c.69A>T p.L23F RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87864538A>T c.69A>T p.L23F RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References