PTEN L325F
Gene Variant Detail

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Gene PTEN
Variant L325F
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN L325F lies within the C2 tensin-type domain of the Pten protein (UniProt.org). L325F results in a loss of phosphatase activity through failure to inhibit Akt phosphorylation in cell culture (PMID: 19329485), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN L325F

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Transcript NM_000314.8
gDNA chr10:g.87961065C>T
cDNA c.973C>T
Protein p.L325F
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_001304717.5 chr10:g.87933213_87933215delCTAinsTTT c.973_975delCTAinsTTT p.L325F RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87961065C>T c.973C>T p.L325F RefSeq GRCh38/hg38
NM_001304717.2 chr10:g.87933213_87933215delCTAinsTTT c.973_975delCTAinsTTT p.L325F RefSeq GRCh38/hg38
NM_000314 chr10:g.87961065C>T c.973C>T p.L325F RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87961065C>T c.973C>T p.L325F RefSeq GRCh38/hg38
NM_001304717 chr10:g.87933213_87933215delCTAinsTTT c.973_975delCTAinsTTT p.L325F RefSeq GRCh38/hg38

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  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References