PTEN L325F
Gene Variant Detail

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Gene PTEN
Variant L325F
Impact List missense
Protein Effect loss of function - predicted
Gene Variant Descriptions PTEN L325F lies within the C2 tensin-type domain of the Pten protein (UniProt.org). L325F results in a loss of phosphatase activity through failure to inhibit Akt phosphorylation in cell culture (PMID: 19329485), and therefore, is predicted to lead to a loss of Pten protein function.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN inact mut PTEN L325F

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Transcript NM_000314.8
gDNA chr10:g.87961065C>T
cDNA c.973C>T
Protein p.L325F
Source Database RefSeq
Genome Build GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

  • Generally, the default sort order for tables is set to be first column ascending; however, specific tables may set a different default sort order.
  • Click on any column header arrows to sort by that column
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