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Gene PTEN
Variant T401I
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PTEN T401I lies within the PDZ domain-binding region of the Pten protein (UniProt.org). T401I demonstrates phosphatase activity (PMID: 10866302, PMID: 30993208) and subcellular localization (PMID: 30993208) similar to wild-type Pten in culture, but has impaired regulation of Glut1 plasma membrane expression and glucose uptake (PMID: 29117568), and therefore, its effect on Pten protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PTEN mutant PTEN T401I

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Transcript NM_000314.8
gDNA chr10:g.87965462C>T
cDNA c.1202C>T
Protein p.T401I
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_000314 chr10:g.87965462C>T c.1202C>T p.T401I RefSeq GRCh38/hg38
NM_000314.8 chr10:g.87965462C>T c.1202C>T p.T401I RefSeq GRCh38/hg38
NM_000314.6 chr10:g.87965462C>T c.1202C>T p.T401I RefSeq GRCh38/hg38

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  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
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  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References