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Gene PIK3CA
Variant C420G
Impact List missense
Protein Effect unknown
Gene Variant Descriptions PIK3CA C420G lies within the C2 PI3K-type domain of the Pik3ca protein (UniProt.org). The functional effect of C420G is conflicting, as it results in increased Akt phosphorylation and cell proliferation, and is transforming in cell culture in one study (PMID: 18074223), however in another study, induces similar cell proliferation and cell viability compared to wild-type Pik3ca, in two different cell lines (PMID: 29533785), and therefore, its effect on Pik3ca protein function is unknown.
Associated Drug Resistance
Category Variants Paths

PIK3CA mutant PIK3CA exon8 PIK3CA C420G

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Transcript NM_006218.4
gDNA chr3:g.179210192T>G
cDNA c.1258T>G
Protein p.C420G
Source Database RefSeq
Genome Build GRCh38/hg38
Transcript gDNA cDNA Protein Source Database Genome Build
NM_006218.3 chr3:g.179210192T>G c.1258T>G p.C420G RefSeq GRCh38/hg38
XM_006713658.4 chr3:g.179210192T>G c.1258T>G p.C420G RefSeq GRCh38/hg38
NM_006218.4 chr3:g.179210192T>G c.1258T>G p.C420G RefSeq GRCh38/hg38
NM_006218 chr3:g.179210192T>G c.1258T>G p.C420G RefSeq GRCh38/hg38
XM_006713658.5 chr3:g.179210192T>G c.1258T>G p.C420G RefSeq GRCh38/hg38
XM_006713658 chr3:g.179210192T>G c.1258T>G p.C420G RefSeq GRCh38/hg38
XM_011512894 chr3:g.179210192T>G c.1258T>G p.C420G RefSeq GRCh38/hg38
XM_011512894.2 chr3:g.179210192T>G c.1258T>G p.C420G RefSeq GRCh38/hg38

Filtering

  • Case insensitive filtering will display rows if any text in any cell matches the filter term
  • Use simple literal full or partial string matches
  • Separate multiple filter terms with a space. Any order may be used (i. e. a b c and c b a are equivalent )
  • Filtering will only apply to rows that are already loaded on the page. Filtering has no impact on query parameters.
  • Use quotes to match on a longer phrase with spaces (i.e. "mtor c1483f")

Sorting

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Molecular Profile Indication/Tumor Type Response Type Therapy Name Approval Status Evidence Type Efficacy Evidence References